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Application of high performance liquid chromatography to the analysis of cilazapril in bulk and pharmaceutical formations

Petikam Lavudu, Avula Prameela Rani, Chandra Bala Sekaran

Abstract


A rapid, selective, precise and accurate high-performance liquid chromatography method for the estimation of cilazapril (CZP) in bulk and pharmaceutical formulations has been developed and validated. The assay of the cilazapril was performed on a Cyano Column (150 mm x 4.6 mm, 5 μm particle size) with UV detection at 212 nm. The mobile phase consists of a formate buffer (pH 3.75)-acetonitrile (60:40 v/v) and a flow rate of 1 ml/min was maintained. The calibration curve was linear over the range of 2–200 μg/ml (r2= 0.9990). The proposed method was validated as per International Conference on Harmonization guidelines. The proposed method was successfully applied to the quantification of (CZP) in pharmaceutical formulations. The proposed method will be useful for routine quality control analysis of (CZP)

Keywords


Cilazapril, Cyano column, HPLC analysis, Pharmaceutical formulations

Full Text: PDF

DOI: 10.26265/e-jst.v9i5.809

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