Evaluation and optimization of Combined gum mixture as matrix former biomaterial in Drug Delivery

Abstract

In the present investigation, two novel gum mixtures were evaluated as controlled release polymer. The ghatti gum obtained from Anogeissus latifolia and Konjac glucomannan from Amorphophallus konjac was evaluated as base polymer for controlled delivery of model drug diclofenac sodium. The prepared synergistically acting gums were evaluated for compatibility study using FT-IR. The diclofenac sodium tablets were evaluated for hardness, friability, weight variation and drug content. The in vitro dissolution study confirmed that the controlled release behavior is mainly due to konjac glucomannan proportion and optimum concentration ratio for ghatti: konjac glucomannan was 30:70