Candidiasis in HIV-positive patients in Greece: Conventional epidemiological data and evaluation of the clinical resistance of Candida species to seven antifungal agents

Abstract

The purpose of this study was the determination of the resistance of different Candida species isolated from oropharengeal and esophageal lesions of HIV positive and AIDS patients over a ten year period, from patients in a Special Infection Unit. Clinical resistance of culture-identified isolates to ketoconazole, itraconazole, fluconazole, voriconazole, 5-flucytosine, amphotericin Β and capsofungin showed variation according to the administered antiretroviral regimen (Protein Inhibitors, Other HAART or no HAART) and different incidence and resistance values were clearly observed among both C. albicans and non –C. albicans species depending on the antifungal compound used