Formation and statistical optimization of the time controlled pulsatile release Propanolol Hydrochloride compressed coated tablet

Abstract

The Purpose of present investigation was to evaluate statical influence different concentration of hydroxy propyl methyl cellulose K4M and ethyl cellulose on Propranolol hydrochloride release compression coated tablet using 32  full factorial design. Tablets were prepared by direct compression technique. Time controlled pulsatile Propranolol hydrochloride tablets containing 40 mg of Propranolol hydrochloride were developed using different ratio of hydroxypropyl methylcellulose and ethyl cellulose that retard the drug release in the physiological environment of stomach and 2-3 hr in intestine. Formulation was optimized on basis of acceptable tablet properties and in vitro drug release. To analyse the release mechanism of optimize batch zero order, first order, Higuchi, Hixson Crowell, Korsmeyer–Peppas kinetic model were used. The kinetics release of optimize batch F3 was best explained by zero order model, Hixson Crowell, and Korsmeyer–Peppas kinetic model