Myeloproliferative diseases and Cytokines

Abstract

Chronic myeloproliferative diseases (MPDs) are disorders with mutually clonal, morphological, pathophysiological and clinical characteristics. Classic MPDs include chronic myelogenous leukemia (CML), polycythemia vera, chronic idiopathic myelofibrosis (AMM, agnogenic myeloid metaplasia) and essential thrombocytosis. MPDs usually exhibit terminal myeloid cell expansion in the peripheral blood. In addition it is common the propensity to shift one syndrome to another, with the existence of intermediate forms and the outcome to transform into acute myeloid leukemia. Another complication shared among the MPDs is the significant risk of thrombohemorrhagic complications, which is most pronounced in patients with PV and ET. The aim of this study was to investigate cytokines TNF-a, IL-1b, IL-2, IL-6, IL-10 and IL-13 in patients with MPD. It can be concluded that: IL-1b is positively related to IL-13. IL-2 is positively related to Hb (possible relation with haematopoiesis). IL-6 is negatively related to Urea. IL-10 is negatively related to Creatinine and alkaline phosphate. IL-13 is negatively related to WBC and positively related to ALP (possible negative relation to body defence against infectious)